Recognizing that research results may not be available by the general abstract submission deadline, late-breaking recognizes novel and critically important research developments. This research should have become available for public dissemination after the abstract submission deadline and prior to the beginning of the HCII 2025 meeting. It should be of major clinical or scientific interest and not just an extension or a replication of work that has been published or presented elsewhere.

The abstracts are peer-reviewed by a panel of experts and selected for oral presentation in one of the scientific late-breaking sessions. The presentation time for the late-breaking papers is limited to 12 minutes, with 3 additional minutes for questions. These presentations will not be published in the conference proceedings.

Abstracts must be submitted no later than March 6, 2025. They must report new, urgent and clinically significant research that could not have been anticipated before the regular abstract submission deadline. If an abstract is already being presented or will be presented identically at another meeting, authors must provide a statement explaining why the study meets late-breaking criteria.

A previous study by our group found that presenting at the late-breaking trials session of a scientific meeting was associated with enhanced journal publication rates for RCTs subsequently analyzed in high-ranking journals. However, it is difficult to determine whether this increased publication rate resulted from the selection process at ACC or because the late-breaking trial presentations stirred up enough editorial interest in the journals to overcome normal biases toward positive results. In any event, it is clear that there are many discrepancies between meeting abstracts and subsequent full-length journal articles. For example, in 6 of the 148 late-breaking abstract/manuscript pairs we evaluated (4%), the treatment effect estimate differed by more than 1 SD and was statistically significant in only one member of the pair.